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| Abbreviation | Definition |
|---|---|
| IRIG | Inertial Rate Integrating Gyro |
| IRIS | Intelligent Rotation In Space |
| IRIS | Italian Research Interim Stage |
| IRIS | Infrared Radiation Interferometer Spectrometer |
| IRL | Intermediate Range Lander |
| IRL | Initiating Reference Letter |
| IRL | Interface Requirement List |
| IrLAP | Infrared Link Access Protocol |
| IrLMP | Infrared Link Management Protocol |
| IRM | Integrated Resource Man |
| IRMA | Intra-Retinal Microvascular Anomaly |
| IRMC | International Radio Maritime Committee |
| IRME | Initiator Resistance Measuring Equipment |
| IRMM | Institute of Reference Materials and Measurements |
| IRMP | Information Resources Management Plan |
| IRN | Interface Revision Notice |
| IRNA | Iranian News Agency |
| IRO | International Refugee Organisation |
| IRP | I/O Request Packet |
| IRP | Iron Regulatory Protein |
| IRP | Integrated Resource Planning |
| IrPHY | Irda Serial Infrared Physical Layer Link Specification |
| IRPM | Information Resource Program Manager |
| IrPnP | Irda Plug And Play Extensions To Irlmp |
| IRPP | Institute For Research On Public Policy |
| IRQ | Interrupt Request |
| IRQL | Interrupt Request Level |
| IRR | Institute of Restoration and Reclamation |
| IRR | Inspection Rejection Report |
| IRR | Integral Rocket Ramjet |
| IRR | Ionising Radiation Regulations |
| IRRI | International Rice Research Institute |
| IRRO | Indian Reprographic Rights Organization |
| IRS | Indian Revenue Service |
| IRS | Indian Remote Sensing Satellite; Indian Revenue Service |
| IRS | Insulin Receptor Substrate |
| IRS | Insulin Resistance Syndrome |
| IRS | Inertial Reference System |
| IRS | International Relief Service |
| IrTinyTP | Infrared Tiny Transport Protocol |
| IRTS | Indian Railway Traffic Service |
| IRU | Inertial Reference Unit |
| IRV | Inspiratory Reserve Volume |
| IRV | Improved Inter-Range Vector |
| IRV | Isotope Reentry Vehicle |
| IRV | Incident Response Vehicle |
| IS | In Situ |
| IS | Intercostal Space |
| IS | Information Systems |
| ISA | Industry Standard Architecture |
