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| Abbreviation | Definition |
|---|---|
| IsA | Interstitial Acute |
| ISA | Independent Safety Assessor |
| ISA | Interim Stowage Assembly |
| ISA | International Seabed Authority |
| ISAC | Immune System Activation Of Coagulation |
| ISAF | International Security Assistance Force |
| ISAM | Information Security Awareness Month |
| ISAMS | Improved Stratospheric And Mesospheric Sounder |
| ISAS | Institute of Space and Astronautical Science |
| ISB | International Society of Biometeorology |
| ISBE | International Society of the Built Environment |
| ISBM | Injection Stretch Blow Molding |
| ISBP | International Society of Breast Pathology |
| ISBT | Inter State Bus Terminus |
| ISBT | International Society For Blood Transfusion |
| ISBZ | IsoStearyl BenZoate |
| ISC | Interface Select Code |
| ISC | Ignore System Crash |
| ISC | Interconnect Standard Consortium |
| ISC | Independent Search Consultant |
| ISC | Interstellar Space Craft |
| ISC | Initial Software Configuration Map |
| ISC | International Seismological Center |
| ISCC | Inter-Society Color Council |
| ISCC | Information System to Support Calibrations |
| ISCCP | International satellite Cloud Climatology Project |
| ISCCP | International Satellite Cloud Climate Project |
| ISCO | International Society for Cellular Oncology |
| ISCO | Innermost Stable Circular Orbit |
| ISCO | International Standard Classification of Occupations |
| ISCON | Indian Steel Construction Company |
| ISCS | International Space Communications System |
| iSCSI | Internet Small Computer System Interface |
| iSCSI | Internet Small Computer Systems Interface |
| ISD | International Subscriber Dialling |
| ISD | Intrinsic Sphincter Deficiency |
| ISD | Instructional Systems Development |
| ISD | Independent School District |
| ISD | Information Services Division |
| ISD | Investment Services Directive |
| ISD | Information Storage Device |
| ISD | Income Support Division |
| ISD | Imperial Star Destroyer |
| ISD | Internal Security Division |
| ISD | Individual Soldier Detector |
| ISD | Industrial Support Detachment |
| ISD | Interface State Density |
| ISD | Improved Standard Driver |
| ISD | Instructional Support Department |
| ISDL | International Sustainable Development Law |
