| Abbreviation | Definition |
|---|---|
| SOMD | Space Operations Mission Directorate |
| SOMF | Start of Minor Frame |
| SOMS | Shuttle Orbiter Medical System |
| SONAR | Sound Navigation And Ranging |
| SONET | Synchronous Optical Network |
| SOP | Stop and Order Pizza |
| SOP | Science Operations Plan |
| SOP | Systems Operation Plan |
| SOP | Subsystem(s) Operating Procedure |
| SOP | Subsystem Operating Program |
| SOP | Standard Operating Procedure |
| SOP | Spacelab Opportunity Payload |
| SOP | Secondary Oxygen Pack |
| SOP | Standard Operating Procedures |
| SOP | Safe Operating Practice |
| SOPC | Shuttle Operations Planning Complex |
| SOPC | Shuttle Operations and Planning Center |
| SOQ | Statements Of Qualifications |
| SOR | Stable Orbit Rendezvous |
| SOR | Specification Operational Requirement |
| SORD | Systems Operations and Requirements Document |
| SORPTR | South Repeater |
| SORT | Instruct DOS to SORT text data |
| SORTIE | Short Term Mission |
| SOS | Save Our Souls |
| SOS | Swap Operating Shell |
| SOS | Sun Orange Small |
| SOS | Stabilized Optical Sight |
| SOS | Source of Supply |
| SOS | Serial Output Special |
| SOSA | Special Operations Support Area |
| SOSC | Space Operations Support Center |
| SOSM | Strap-on Solid Motor |
| SOT | Science Operations Team |
| SOT | Sea Of Tranquility |
| SOT | Strap-on Tank |
| SOT | Solar Optical Telescope |
| SOTA | Science Operations and Test Area |
| SOTP | Seat Of The Pants |
| SOTS | Seat Of The Pants |
| SOUP | Solar Optical Universal Photopolarimeter |
| SOV | Solenoid Operated Valve |
| SOW | Statements of Work |
| SP | Superintendent of Police |
| SP | Single Precision |
| SP | Stack Pointer |
| SP | System Procedure |
| SP | Service Pack |
| SP | Street Photography |
| SP | Senior Pastor |