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| Abbreviation | Definition |
|---|---|
| SPDT | Shadow Page Directory Table |
| SPE | Special Police Establishment |
| SPEED | Social Pact for Empowered Economic Development |
| SPELT | Soros Professional English Language Teacher |
| SPEM | Spasmolytic Polypeptide Expressing Metaplasia |
| SPF | Software Production Facility |
| SPF | Single Point Failure |
| SPFA | Single Point Failure Analysis |
| SPFP | Single Point Failure Potential |
| SPG | Special Protection Group |
| SPG | Strategic Placement Group |
| SPG | Single Point Ground |
| SPG | Signal Point Ground |
| SPHR | Senior Professional in Human Resources Certification |
| SPHR | Senior Professional Human Resources |
| SPI | SCSI Parallel Interface |
| SPI | Superintendent of Public Instruction |
| SPI | Surface Position Indicator |
| SPI | Standard Practice Instruction |
| SPI | Sow Productivity Index |
| SPIAP | Shuttle/Payload Integration Activities Plan |
| SPIC | Space Programs Information Coalition |
| SPICE | Spacecraft Planets Instrument Constants And Events |
| SPICE | Spacelab Payload Integration and Coordination in Europe |
| SPID | Service Profile Identifier |
| SPIDF | Support Planning Identification File |
| SPIDPO | Shuttle Payload Integration and Development Program Office |
| SPIF | Standard Payload Interface Facility |
| SPIF | Shuttle/POCC Interface Facility Function |
| SPIF | Shuttle Payload Integration Facility |
| SPII | Shuttle Program Implementation Instruction |
| SPIMS | Shuttle Program Information Management System |
| SPIP | Solid Propulsion Integrity Program |
| SPIS | Spacecraft Plasma Interaction System |
| SPK | Spacecraft And Planet Kernel |
| SPL | Set Priority Level |
| SPL | Set Processor Level |
| SPM | Software Project Management |
| SPM | Set Program Mask |
| SPM | Site Project Manager |
| SPM | Software Programmers Manual |
| SPM | Security Program Manager |
| SPML4T | Shadow Page Map Level - 4 Table |
| SPO | Strategic Planning Office |
| SPOC | Shuttle Payload Operations Contractor |
| SPOF | Software Project Management |
| SPOF | Science Planning and Operations Facility |
| SPOHNC | Support for People with Oral and Head and Neck Cancer |
| SPOM | Site Project Manager |
| SPOM | STS Planning and Operations Management |
